I'm now maybe at the 10% of the game, but I can't really tell. I am now at a point where I have found 5 cores, and went to 2 places that did not have cores in them. In Bastion, you begin to explore the world the game is set in, get used to the individual aspects of gameplay, plot, etc. So, I started playing Bastion, and this experience got me thinking about the general structure of games. Which is kind of a spoiler anyway.īastion specific part (Don't read this if you haven't played Bastion yet and plan to play it in the future!) I will not give plot spoilers, but I will go into detail about the structure of the game. Warning: it is strongly recommended to play Bastion before you read the first part of this post. r/CoOpGaming - A community for co-op gaming r/xboxone - Xbox-specific subreddit for general Xbox news and discussion r/playstation, /r/PS4 & /r/PS5 - PlayStation-specific subreddits for general PlayStation news and discussion r/pcgaming - PC gaming-specific subreddit for general PC gaming news, discussion and gaming tech support r/nintendo - Nintendo-specific subreddit for general Nintendo news and discussion r/shouldibuythisgame - Find out what's worth getting. r/gamingsuggestions - Go here to help you find your next game to play r/gaming4gamers - Discussion, bar the Hivemind
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Sources: NBA Advanced Stats,, ESPN, Dunks & Threes, BBallIndex Minimum 1,000 minutes played for a single team in the season for all metrics except Dunks & Threes (minimum 1,200 minutes). Top five player-seasons in four defensive metrics FiveThirtyEight defensive RAPTOR, since 1977ĮSPN defensive Real Plus-Minus, since 1996ĭunks & Threes defensive Estimated Plus-Minus, since 2004 There’s no consensus on defense … except for Rudy Fellow Jazzman Mike Conley, for instance, holds the NBA’s second-highest defensive on/off differential this year among those high-volume players - but that’s partially because Conley has played over 90 percent of his minutes alongside Gobert. Raw on/off figures, though, don’t account for additional context like teammate or opponent performance, which can be significant. Minimum 1,000 minutes played for a single team in the season. High-volume NBA players by greatest difference in team points allowed per 100 possessions when that player is on the court vs. In fact, Gobert’s defensive on-off split is one of the largest of any high-volume player over the past 15 years: That’s the largest such gap in the NBA among players with at least 1,000 minutes. This season, the Jazz are 11.9 points per 100 possessions better defensively when the Frenchman plays compared with when he sits, per Cleaning the Glass. Gobert’s play is the primary driver behind Utah’s top-ranked per-possession defense outside garbage time. While his competitors may disagree, the data suggest that not only is Utah Jazz center Rudy Gobert running away with this year’s award, he’s having one of the best defensive seasons in modern NBA history. The 2020-21 Defensive Player of the Year Award serves as one such instance. Certain seasons are so exemplary that viewing them only in the context of same-year contemporaries sells them badly short. End-of-year NBA awards are a good lens through which to evaluate the league’s best performances, but the framing isn’t always quite right. Furthermore, we found that the expression of a specific and major PKC substrate, myristoylated alanine-rich C-kinase substrate (MARCKS) ( Aderem, 1992a), was necessary for PKC activation to promote muscle cell spreading ( Disatnik et al., 2002). We reported distinct roles for three different PKC isozymes, α, δ, and ϵ, in integrin-mediated muscle cell spreading ( Disatnik et al., 2002). The activation of PKC has been shown to be an important intermediate step in integrin-mediated cell spreading and focal adhesion formation in different cell types ( Woods and Couchman, 1992 Vuori and Ruoslahti, 1993 Schlaepfer et al., 1994 Haimovich et al., 1996). Myoblasts deficient in α5β1 integrin or myoblasts in which PKC has been inhibited fail to spread on fibronectin ( Disatnik and Rando, 1999). These studies have shown that the binding of α5β1 integrin to its receptor, fibronectin, leads to the activation of protein kinase C (PKC), which is necessary for the cells to adhere and spread. We have studied the mechanisms by which integrin activation promotes adhesion and spreading of muscle cells ( Disatnik and Rando, 1999 Disatnik et al., 2002). These results demonstrate a direct biochemical pathway linking α5β1 integrin signaling to cytoskeletal dynamics and involving bi-directional translocation of MARCKS during the dramatic changes in cellular morphology that occur during cell migration and tissue morphogenesis. All of these processes are directly dependent on the binding of α5β1 integrin to its extracellular matrix receptor, fibronectin. The dephosphorylation of MARCKS and its translocation back to the membrane permits the later stages of cell spreading during the polymerization and cross-linking of actin and the maturation of the cytoskeleton. Using MARCKS mutants that are defective in membrane association or responsiveness to PKC-dependent phosphorylation, we demonstrate that the translocation of MARCKS from the membrane to the cytosol in a PKC-dependent manner permits the initial phases of cell adhesion. Here we show that myristoylated alanine-rich C-kinase substrate (MARCKS) a specific substrate of protein kinase C (PKC), is regulated by α5β1 integrin-mediated activation of PKC and is critical to the regulation of actin stress fiber formation during muscle cell spreading. Cell-matrix interactions mediated by integrins regulate cytoskeletal dynamics, but the signaling cascades that control these processes remain largely unknown. The regulation of the cytoskeleton is critical to normal cell function during tissue morphogenesis. In addition, it allows applications to breathe peacefully with the ability to free up RAMĪlso, this software optimizes your slower Mac and makes it 4 times faster than before. 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The Live Nation-produced trek, originally planned for the summer of 2020, then moved to June to November this year, launches in mid-July at the home of the Chicago Cubs and runs through early December in Knoxville, Tenn., before picking up again in April 2022. July 30-Mountain Home, ID-Mountain Home Country Music FestivalĪugust 4-Prairie Du Chien, WI-Country on the RiverĪugust 5-St.Chris Stapleton’s lengthy All-American Road Show has been revamped again, with 18 shows added. July 29-Central Point, OR-Country Crossings Music Festival July 21-Wantagh, NY-Northwell Health at Jones Beach Theater# July 16-Darien Lake, NY-Darien Lake Performing Arts Center# July 15-Hartford, CT-The XFINITY Theatre# June 29-Chicago, IL-Wrigley Field†† (SOLD OUT) June 24-North Platte, NE-Nebraskaland Days June 17-Indianapolis, IN-Klipsch Music Center# (on-sale March 3) June 16-Cincinnati, OH-Riverbend Music Center# June 15-Charleston, WV-Charleston Civic Center# June 10-Birmingham, AL-Oak Mountain Amphitheatre# June 9-Southaven, MS-BankPlus Amphitheater at Snowden Grove# June 3-Wheatland, CA-Toyota Amphitheatre§ June 2- Mountain View, CA-Shoreline Amphitheatre§ June 1-Fresno, CA-Save Mart Center at Fresno State§ (on-sale March 10) May 23-Denver, CO-Red Rocks Amphitheatre§ May 18-San Diego, CA-Mattress Firm Amphitheatre§ May 12-Raleigh, NC-Coastal Credit Union Music Park at Walnut Creek§ May 11-Virginia Beach, VA-Veterans United Home Loans Amphitheater at VA Beach§ May 5-Alpharetta, GA-Verizon Amphitheatre§ Lauderdale, FL-Tortuga Music FestivalĪpril 20-Roanoke, VA-Berglund Center‡ (SOLD OUT)Īpril 21-Pikeville, KY-East Kentucky Expo Center‡ (SOLD OUT)Īpril 22-Pikeville, KY-East Kentucky Expo Center‡ (SOLD OUT)Īpril 28-Cape Girardeau, MO-Show Me Center+ (SOLD OUT)Īpril 29-Bloomington, IL-U.S. March 30-Las Vegas, NV-Pearl Theater – Palms Casino Resort† (SOLD OUT)Īpril 6-Columbus, GA-Columbus Civic Center† (SOLD OUT)Īpril 8-Ft. March 24-Calgary, AB-Scotiabank Saddledome* March 19-Ottawa, ON-Canadian Tire Centre* March 18-London, ON-Budweiser Gardens* (SOLD OUT) “CHRIS STAPLETON’S ALL-AMERICAN ROAD SHOW” 2 on the Billboard Country Albums chart with more than 27,000 albums sold, making it one of the best-selling first weeks by a debut country artist in 2015. Released last May 2015 on Mercury Records Nashville, Traveller initially debuted at No. The extensive 2017 tour follows a series of seminal years for Stapleton since the release of his breakthrough double Platinum solo debut album Traveller. For full details, visit – stapleton – tour – 2017/. The tour will offer two premium VIP packages on tour, including an interactive collection of instruments and memorabilia. The will be a pre-sale beginning Tuesday, February 21 at 10:00 AM for Citi cardmembers. Tickets for the new shows and the Saint Louis show go on sale to the general public beginning Friday, February 24 at 10:00 AM through, or at the venue box office ( The Gold’s Gym Box office at Hollywood Casino Amphitheatre in Saint Louis). Photo by Sean Derrick/Thyrd Eye Photography Stapleton will be promoting his new, yet unnamed album May 5, exactly two years to the day in which his breakout smash album Traveller was released. The tour officially kicks off March 9 in Houston, TX and winds through Canada and the United States before winding up August 19 in Gilford, NH. It even includes a stadium date with Tom Petty at Wrigley Field in Chicago on June 29 as well as a couple of dates at Summerfest in Milwaukee, WI. This tour will be the first to feature large amphitheatres and arenas. The show will mark the third time in just over a year for the 2015/2016 breakout star. 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If it seems as though the Surface machine sprang up out of nowhere, that's only because Microsoft has been unusually secretive about it. Its interface is the exact opposite of the personal computer: cooperative, hands-on, and designed for public spaces. And the Surface has the added advantage of a horizontal screen, so several people can gather around and use it together. Multitouch devices accept input from multiple fingers and multiple users simultaneously, allowing for complex gestures, including grabbing, stretching, swiveling and sliding virtual objects across the table. It is an idea that has been floating around the research community since the 1980s and is swiftly becoming a hip new product interface - Apple's new iPhone has multitouch scrolling and picture manipulation. One of the key components of surface computing is a "multitouch" screen. Surface computing uses a blend of wireless protocols, special machine-readable tags and shape recognition to seamlessly merge the real and the virtual world - an idea the Milan team refers to as "blended reality." The table can be built with a variety of wireless transceivers, including Bluetooth, Wi-Fi and (eventually) radio frequency identification (RFID) and is designed to sync instantly with any device that touches its surface. The name Surface comes from "surface computing," and Microsoft envisions the coffee-table machine as the first of many such devices. I'm not often surprised by new technology, but I can honestly say I'd never seen anything like it. He was dragging and dropping virtual content to physical objects. Then, Gattis put a cellphone on the surface and dragged several photos to it - just like that, the pictures uploaded to the phone. Using two fingers, he pulled the corners of a photo and stretched it to a new size. As Gattis touched and dragged each picture, it followed his fingers around the screen. Instantly, digital pictures spilled out onto the tabletop. Gattis took out a digital camera and placed it on the Surface. For that matter, it has no keyboard, no mouse, no trackball - no obvious point of interaction except its screen. Surface has no cables or external USB ports for plugging in peripherals. One of Gattis's consumer pain points is the frustrating mess of cables, drivers and protocols that people must use to link their peripheral devices to their personal computers. He spoke in sentences peppered with "application scenarios," "operational efficiencies" and "consumer pain points" while he took me through a few demonstrations of what the Surface can do. He's a clean-cut fellow who is obviously the veteran of a thousand marketing seminars. The product behind the Milan project is called the Microsoft Surface, and the company's unofficial Surface showman is Jeff Gattis. Inside that room was Microsoft's best-kept technology secret in years. My hosts politely threatened legal consequences if I blabbed about the project to anyone not directly involved in it, then escorted me down a dark hallway to a locked corner conference room. This past March, when the project was still operating on the down low, I became the first reporter invited inside these offices. About 4 miles away, however, there is an unnumbered building that is decidedly "off campus." In that building, Microsoft has quietly been developing the first completely new computing platform since the PC - a project that was given the internal code name Milan. The Microsoft Visitor Center, for instance, is in Building 127, north campus, while the Microsoft Conference Center is in Building 33, just down the road from the company soccer and baseball fields. To make sense of it all, you have to navigate by numbers. Microsoft's corporate campus is a sprawling affair, with more than 100 buildings scattered over 261 acres. Play icon The triangle icon that indicates to play Remote Desktop Connection’s multiple monitor feature can support two types of monitor configurations: If you have access to those editions and can provide additional information, please let us know in the discussion thread below. Note: I didn’t include Windows 7 Home Basic/Premium or Windows 10 Education in the table because I don’t have access to those editions to test. Figure C Only specific editions of Windows can function as the Remote System in a multiple monitor arrangement. The table in Figure C shows the breakdown. To successfully use multiple monitors with Remote Desktop Connection, you need to understand that while most editions of Windows can function as the Local System, only certain editions of Windows can function as the Remote System. Figure B It’s easier to understand how this works with clear terminology. I’ll refer to the computer that you as a user are sitting in front of as the Local System and the computer that’s in another location, the one you want to connect to, as the Remote System ( Figure B). The term Remote Desktop can be a bit ambiguous, as it’s often used to refer to the computers on both ends of the connection. Figure A Getting Remote Desktop Connection to work in a multiple monitor arrangement entails more than just selecting the Use All My Monitors For The Remote Session check box. Let’s take a closer look at how to use Remote Desktop Connection with multiple monitors in Windows 10, as well as in Windows 7 and 8.1. However, it’s a bit more complex than that, as you need to have the correct editions of Windows on the correct ends of the connection. Since it’s a simple check box that’s available in all versions of Windows, it’s easy to think that all you have to do to enable multiple monitor support for a Remote Desktop Connection is select it. On the Display tab of the Remote Desktop Connection dialog box, you’ll find the Use All My Monitors For The Remote Session check box, as shown in Figure A. Unfortunately, there isn’t a lot of accurate information about which editions of Windows support a multiple monitor Remote Desktop configuration, which causes a lot of confusion. Recently I’ve been receiving questions about the requirements for configuring and using Windows Remote Desktop Connection in a multiple monitor arrangement under Windows 10. Setting up Remote Desktop in a multiple-monitor scenario isn't complicated-but you have to know which editions support the feature. Which Windows editions let you use Remote Desktop Connection with multiple monitors? We apologize for any inconvenience this may cause. Download your free trial today!ĭue to government restrictions, Webroot WiFi Security service may not be available in the following countries (this depends on ISP, region, and time factor): China, Russia, Egypt, and UAE. 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